Alternative instrumentation for the analysis of total carbon dioxide (TCO2) in equine plasma

Abstract

The analysis of total carbon dioxide (TCO(2)) in equine plasma is conventionally done in Australia and elsewhere using Beckman Synchron EL-ISE(R) analysers. This instrument is no longer being manufactured and has not been supported by the supplier since December 2008. For testing for TCO(2) to continue, it is necessary to evaluate and commission alternative instrumentation. In this paper, we compare the Beckman Synchron EL-ISE, the Beckman Synchron CX5, the Beckman UniCel DxC 600 and the Randox Daytona instruments. Results indicate that all four instruments perform in accordance with the manufacturer's specifications. The Beckman CX 5, DxC 600 and Randox Daytona instruments are therefore all suitable alternatives for routine screening in a laboratory environment. Only the Randox Daytona instrument is sufficiently 'portable', i.e. it can be readily transported and used on-site at a racecourse (typically in a purpose-built modest-size laboratory vehicle). The three Beckman instruments are suitable for 'confirmatory analysis' using the quality-accredited method (Racing Science Centre), but the principle of operation of the Randox Daytona instrument may preclude its use in confirmatory analysis. Instrument costs may affect purchase decisions.