Alternative approaches to asthma

Abstract

On the basis of studies of the pathophysiology of asthma, we now know that agents to control chronic asthma must do more than reverse bronchoconstriction caused by a hyperreactive airway. They must also control the inflammatory response engendered by the triggers of asthma. Three types of antiinflammatory agents are now used for this purpose: corticosteroids, cromolyn sodium, and a new anticholinergic drug, ipratropium bromide. These drugs are discussed in terms of their mechanisms of action, clinical uses, and side effects reported in studies of children with asthma.