Abstract
Blended nanofibrous biomaterials from natural and synthetic sources show promise for better biointegration. This study explores high-yield alternating field electrospinning (AFES) of blended cold-water fish skin gelatin (FGEL) and polycaprolactone (PCL) nanofibrous meshes with up to 30 wt% PCL at 7.8–14.4 g/h fiber productivity, depending on the composition. FGEL/PCL nanofibers reveal smooth surface morphology and 237–313 nm average diameters after thermal crosslinking. FTIR analysis indicated little FGEL/PCL interaction and notable changes in PCL crystallinity in the crosslinked nanofibers. A 14-days in-vitro analysis shows good cellular viability and nanofibrous FGEL/PCL mesh stability. Results demonstrate that AFES provides efficient, scalable production of blended FGEL/PCL nanofibrous biomaterials with suitable characteristics.
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