Abstract
Summary Objective Alternate day fasting (ADF; which consists of an ad libitum “feed day” alternated with a 75% energy restriction “fast day”) combined with exercise improves several coronary heart disease (CHD) risk factors. However, the effect of this combination therapy on endothelial function, and the role that adipokines play in mediating this effect, is unknown. Accordingly, this study examined the effect of ADF combined with exercise on brachial artery flow mediated dilation (FMD) and plasma adiponectin and leptin. Research methods and procedures Sixty-four obese subjects were randomized to 1 of 4 groups: 1) combination (ADF + endurance exercise), 2) ADF, 3) exercise, or 4) control, for 12 weeks. Results Body weight decreased ( P P P P P P Conclusions These findings suggest that ADF alone is an effective intervention to improve vascular endothelial function. However, the role of adipokines in mediating this effect is still unclear.
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