Abstract
ObjectivePsychotic symptoms are quite common in patients with pediatric bipolar disorder (PBD) and may affect the symptom severity and prognosis of PBD. However, the potential mechanisms are less well elucidated until now. Thus, the purpose of this study was to investigate the brain functional differences between PBD patients with and without psychotic symptoms.MethodA total of 71 individuals including: 27 psychotic PBD (P-PBD), 25 nonpsychotic PBD (NP-PBD), and 19 healthy controls were recruited in the present study. Each subject underwent 3.0 Tesla functional magnetic resonance imaging scan. Four-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) was employed to detect the local brain activity changes. Analyses of variance (ANOVA) were used to reveal brain regions with significant differences among three groups groups of individuals, and inter-group comparisons were assessed using post hoc tests.ResultsThe ANOVA obtained significant among-group FOCA differences in the left triangular inferior frontal gyrus, left supplementary motor area, left precentral gyrus, right postcentral gyrus, right superior occipital gyrus, and right superior frontal gyrus. Compared with the control group, the P-PBD group showed decreased FOCA in the left supplementary motor area and bilateral superior frontal gyrus and showed increased FOCA in the left triangular inferior frontal gyrus. In contrast, the NP-PBD group exhibited decreased FOCA in the right superior occipital gyrus and right postcentral gyrus and showed increased FOCA in the left orbital inferior frontal gyrus. Compared to the NP-PBD group, the P-PBD group showed decreased FOCA in the right superior frontal gyrus.ConclusionThe present findings demonstrated that the two groups of PBD patients exhibited segregated brain functional patterns, providing empirical evidence for the biological basis of different clinical outcomes between PBD patients with and without psychotic symptoms.
Highlights
Pediatric bipolar disorder (PBD) receives more and more attention owing to the atypical symptoms, prolonged disease duration, more functional impairments, and resistance to treatment [1]
The present findings demonstrated that the two groups of PBD patients exhibited segregated brain functional patterns, providing empirical evidence for the biological basis of different clinical outcomes between PBD patients with and without psychotic symptoms
Our recent study focusing on PBD found that PBD patients with psychotic features were associated with extensive structural abnormalities mainly located in the cortical-subcortical-limbic network, whereas non-psychotic PBD patients exhibited GM deficits in limited cortical regions [9]
Summary
Pediatric bipolar disorder (PBD) receives more and more attention owing to the atypical symptoms, prolonged disease duration, more functional impairments, and resistance to treatment [1]. Our recent study focusing on PBD found that PBD patients with psychotic features were associated with extensive structural abnormalities mainly located in the cortical-subcortical-limbic network, whereas non-psychotic PBD patients exhibited GM deficits in limited cortical regions [9]. The magnitude of observed effects was significantly correlated with lifetime psychotic symptom severity [10] Another seed-based functional connectivity study revealed that ventral anterior cingulate cortex (vACC) connectivity alterations in BD patients depended on co-occurrence of lifetime psychosis [11]. Taken together, these findings highlight the importance of studies that focus on the effect of psychotic dimension on neuroimaging alterations in BD patients
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
