Abstract
T HERE recently came under our observation a patient who, four weeks prior to admission to the hospital, displayed a negative intradermal test with histoplasmin. Although all clinical studies for histoplasmosis were negative, a repeat intradermal test with histoplasmin shortly after admission was observed to be strongly positive. This aroused our interest in the possibility that repeated intradermal injections of test antigens of this type might transform negative skin reactions to positive ones as a result of altered skin reactivity. To test this possibility, repeated intradermal tests were performed with a variety of antigens in healthy young persons.
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