ALTERED SALIENCE FUNCTIONAL NETWORK CONNECTIVITY AS THE NEURAL BASIS OF NEGATIVE SYMPTOMS IN PATIENTS WITH FIRST-EPISODE PSYCHOSIS AND INDIVIDUALS WITH ATTENUATED PSYCHOSIS SYNDROME

Abstract

Studies have attempted to determine markers that predict the onset of psychosis, and the alteration of brain networks, such as the executive control network (ECN), the default mode network (DMN), and the salience network (SN), which has been reported to be associated with psychosis onset. However, no studies have examined interactions at the functional network level that could adequately account for neural interactions and explain the complex psychotic symptoms encompassing various symptom domains. This study is conducted to determine whether functional network connectivity differs between individuals with attenuated psychosis syndrome (APS), patients with first-episode psychosis (FEP), and healthy controls (HCs). We explored whether the changes are more severe in those who convert to full-blown psychosis and whether functional network connectivity is associated with psychotic symptom severity.