Abstract
Internet gaming disorder (IGD) has become a serious mental health issue worldwide. Evaluating the benefits of interventions for IGD is of great significance. Thirty-six young adults with IGD and 19 healthy comparison (HC) subjects were recruited and underwent resting-state fMRI scanning. Twenty IGD subjects participated in a group craving behavioral intervention (CBI) and were scanned before and after the intervention. The remaining 16 IGD subjects did not receive an intervention. The results showed that IGD subjects showed decreased amplitude of low fluctuation in the orbital frontal cortex and posterior cingulate cortex, and exhibited increased resting-state functional connectivity between the posterior cingulate cortex and dorsolateral prefrontal cortex, compared with HC subjects. Compared with IGD subjects who did not receive the intervention, those receiving CBI demonstrated significantly reduced resting-state functional connectivity between the: (1) orbital frontal cortex with hippocampus/parahippocampal gyrus; and, (2) posterior cingulate cortex with supplementary motor area, precentral gyrus, and postcentral gyrus. These findings suggest that IGD is associated with abnormal resting-state neural activity in reward-related, default mode and executive control networks. Thus, the CBI may exert effects by reducing interactions between regions within a reward-related network, and across the default mode and executive control networks.
Highlights
Internet gaming disorder (IGD) has become a serious mental health issue worldwide
IGD subjects showed significantly lower baseline amplitude of low fluctuation (ALFF) in the right orbitofrontal cortex (OFC) and posterior cingulate cortex (PCC) compared with healthy comparison (HC) subjects (Fig. 1 and Table 1)
Compared with the craving behavioral intervention (CBI)– group, the CBI +group showed reduced resting-state functional connectivity (rsFC) of the OFC with the hippocampus and parahippocampal gyrus, and reduced rsFC of the PCC with the supplementary motor area, precentral gyrus, and postcentral gyrus. These results suggest that resting-state neural activity in reward-related network, default mode network (DMN) and executive control network (ECN) are dysfunctional in IGD
Summary
Internet gaming disorder (IGD) has become a serious mental health issue worldwide. Evaluating the benefits of interventions for IGD is of great significance. In addition to these rsFC findings, studies measuring other indices such as amplitude of low fluctuation (ALFF)[18] have indicated that IGD is associated with altered resting-state neural activity in regions involved in reward processing and attention, including the orbitofrontal cortex (OFC) and precuneus[10].
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