Abstract
Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Previous fMRI studies investigating PBD were mainly task-related. However, little is known about the abnormalities in PBD, especially during resting state. Resting state brain activity measured by fMRI might help to explore neurobiological biomarkers of the disorder. Methods: Regional homogeneity (ReHo) was examined with resting-state fMRI (RS-fMRI) on 15 patients with PBD in manic state, with 15 age-and sex-matched healthy youth subjects as controls. Results: Compared with the healthy controls, the patients with PBD showed altered ReHo in the cortical and subcortical structures. The ReHo measurement of the PBD group was negatively correlated with the score of Young Mania Rating Scale (YMRS) in the superior frontal gyrus. Positive correlations between the ReHo measurement and the score of YMRS were found in the hippocampus and the anterior cingulate cortex in the PBD group. Conclusions: Altered regional brain activity is present in patients with PBD during manic state. This study presents new evidence for abnormal ventral-affective and dorsal-cognitive circuits in PBD during resting state and may add fresh insights into the pathophysiological mechanisms underlying PBD.
Highlights
Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission
The PBD sample consisted of 15 participants with type I BD; none had type II BD, it was not excluded
Our PBD participants were manic by mood ratings (YMRS 36.564.1, Mood and Feelings Questionnaire (MFQ) 10.364.3)
Summary
Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. 1% of adolescents and children have diagnosis of PBD [1]. One study showed that nearly 65% of PBD attempted suicide and almost 75% had been in hospital [2]. A juvenile onset PBD leads to have a higher rate of suicide and substance abuse behavior [3]. Diagnosis of this disorder is based almost entirely on a review of clinical history. Neurobiological studies on pediatric BD may help illustrate the pathophysiological mechanisms of PBD
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