Abstract
Background: Asthma is a chronic disease appeared to be associated with depression. But the underpinnings of depression in asthma remain unknown. In order to understand the neural mechanisms of depression in asthma, we used cerebral blood flow (CBF) to probe the difference between depressed asthmatic (DA) and non-depressed asthmatic (NDA) patients.Methods: Eighteen DA patients, 24 NDA patients and 57 healthy controls (HC) received pulsed arterial spin labeling (pASL) scan for measuring CBF, resting-state functional magnetic resonance imaging (rs-fMRI) scan, severity of depression and asthma control assessment, respectively.Results: Compared to NDA, DA patients showed increased regional CBF (rCBF) in the right cerebellum posterior lobe. Compared to HC, DA, and NDA patients all showed significantly decreased rCBF in the right cerebellum posterior lobe.Conclusions: We showed the first evidence of altered rCBF in the right cerebellum posterior lobe in asthma using pASL, which appeared to be involved in the neuropathology in asthma.Clinical Trial Registration: An investigation of therapeutic mechanism in asthmatic patients: based on the results of Group Cognitive Behavioral Therapy (Registration number: ChiCTR-COC-15007442) (http://www.chictr.org.cn/usercenter.aspx).
Highlights
Asthma was a chronic inflammatory condition that swelled and narrowed the airways, leading to dyspnea, coughing, and tightening of the chest
Rosenkranz et al [6,7,8] explored the neural circuitry underlying the interaction between emotion and asthma symptoms used task functional magnetic response imaging (fMRI), the findings consistently indicated that neurophenotypes of asthma might be identified by neural activity of brain circuits previously implicated in emotion regulation, especially the insula and anterior cingulate cortex (ACC)
We identified regions of interest (ROI) with abnormal regional CBF (rCBF) between DA and non-depressed asthmatic (NDA), healthy controls (HC) groups
Summary
Asthma was a chronic inflammatory condition that swelled and narrowed the airways, leading to dyspnea, coughing, and tightening of the chest. Altered Cerebral Blood Flow in Asthma studies consistently documented that depression was prevalent in patients with asthma, and was associated with uncontrolled asthma and poor quality of life [3,4,5]. Functional magnetic response imaging (fMRI) proved itself a useful technique to detect and quantitate sites of activation in the brain and to map circuits that might be associated with or involved in the underpinnings of emotion in asthma. On the basis of previous studies, Busse [10] summarized minutely how was the central nervous system involved in allergic airway response in asthma and how this related to stress. In order to understand the neural mechanisms of depression in asthma, we used cerebral blood flow (CBF) to probe the difference between depressed asthmatic (DA) and non-depressed asthmatic (NDA) patients
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