Abstract
Objective: The B-cell lymphoma/leukemia-2 (Bcl-2) family of proteins governs mitochondrial membrane permeability where the programmed apoptotic process is controlled by the balance between proapoptotic (Bax) and antiapoptotic (Bcl-2) proteins. We aimed to investigate the [Bcl-2]/[Bax] in different brain regions in a post-traumatic stress disorder rat model.
Highlights
Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by an experience of a traumatic event
It was stated that PTSD is associated with hypoactivity in the ventromedial prefrontal cortex, hyperactivity in the amygdala and reduced volume in the hippocampus [2]
A monozygotic twin study performed in veterans revealed that hippocampal assymetry is associated with PTSD [6]
Summary
Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by an experience of a traumatic event. Affected individuals have intrusive re-experiences of the traumatic events that lack awareness of the context and the time [1]. Neuroanatomical studies have revealed critical involvement of three important brain regions, the hippocampus, the prefrontal cortex and the amygdala. It was stated that PTSD is associated with hypoactivity in the ventromedial prefrontal cortex, hyperactivity in the amygdala and reduced volume in the hippocampus [2]. A monozygotic twin study performed in veterans revealed that hippocampal assymetry is associated with PTSD [6]. A crosssectional magnetic resonance study performed in the veterans of Vietnam Conflict and Persian Gulf War has shown increased amygdala volume of the affected subjects [8]
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