Abstract
Kinases are a class of proteins that play essential roles in cell signaling, differentiation, and proliferation. They are frequently mutated in cancer and are the second-largest therapy target of specific inhibitors in clinical research. The activation status of mutated kinases in cancer can impact phenotypic outcomes not limited to tumor progression and drug sensitivity. Many approaches are implemented to quantify these phenotypic outcomes by controlling cell signaling through introducing mutations in kinase systems.
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