Abstract
Altered Peak C-peptide and Fasting Blood Glucose in Children with Autism Spectrum Disorder
Highlights
Autism spectrum disorder (ASD) refers to a group of complex neurodevelopmental disorders, characterized by deficits in social communication, interaction and demonstrating restricted, repetitive, and stereotyped patterns of behavior
The results showed that fasting blood glucose significantly decreased in children with ASD and two children in the ASD group had impaired glucose tolerance (IGT)
There were no significant differences in fasting insulin, fasting C peptide, insulin resistance index and insulin sensitivity index
Summary
ASD refers to a group of complex neurodevelopmental disorders, characterized by deficits in social communication, interaction and demonstrating restricted, repetitive, and stereotyped patterns of behavior. Centers for Disease Control and Prevention forecasted that the prevalence of ASD would be 1 in 45 in USA [1]. A metaanalysis of the public health and primary care centers in the UK estimated that the prevalence of ASD was 26.6 per 10,000 in mainland, based on eighteen epidemiological studies [2]. Vast clinical heterogeneity is an important feature of ASD. ASD exists tremendous phenotypic heterogeneity in neurological comorbidities, language and cognitive abilities, and adaptive function [3]. ASD patients often have co-occurring seizures, sleep problems,
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