Abstract
The release of nuclear restricted RNA to the cytoplasm in dimethylaminoazobenzene (DAB) and acetylaminofluorene (AAF) induced tumors suggested a basis for the phenotypic expression of chemically induced neoplasms. In this report the increased release of RNA from nuclei in vitro is identified both following acute intoxication and with prolonged (tumor producing) exposure to a third carcinogen, thioacetamide. This release is independent of ATP added in the cell-free system and consistent with “leaky” nuclei, providing further support for the hypothesis that nuclear RNA transport is involved in chemical carcinogenesis.
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