Abstract
A novel isotopic technique suggests that the [Na] and [Cl] of airway surface liquid are both normally ~50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane conductance regulator (CFTR) causes failure of transcellular Cl absorption, resulting in an elevation of [Na] and [Cl] of airway surface liquid to ~100 mM.
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Schedule a callMore From: News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
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