Altered Motor Excitability in Patients With Diffuse Gliomas Involving Motor Eloquent Areas: The Impact of Tumor Grading.

Abstract

Diffuse gliomas have an increased biological aggressivenessacross the World Health Organization (WHO) grading system. The implications of glioma grading on the primary motor cortex (M1)-corticospinal tract (CST) excitability is unknown. To assess the excitability of the motor pathway with navigated transcranial magnetic stimulation (nTMS). Retrospective cohort study of patients admitted for surgery with diffuse gliomas within motor eloquent areas.Demographic, clinical, andnTMS-related variables were collected. The Cortical Excitability Score (CES 0 to 2 according to the number of abnormalinterhemispheric resting motor threshold (RMT) ratios) was calculated for patients where bilateral upper and lower limb mapping was performed. A total of 45 patients were included: 9 patients had a low-grade glioma and 36 patients had a high-grade glioma.The unadjusted analysis revealed an increase in the latency of the motor evoked potential of the lower limb with an increase of the WHO grade (P=.038). The adjusted analysis confirmed this finding (P=.013) and showed a relation between the increase in the WHO and a decreased RMT (P=.037) of the motor evoked responses in the lower limb. When CES was calculated, an increase in the score was related with an increase in the WHO grade (unadjusted analysis-P=.0001; adjusted analysis-P=.001) and in isocitrate dehydrogenase (IDH) wild-type tumors (unadjusted analysis-P=.020). An increase in the WHO grading system and IDH wild-type tumors are associated with an abnormal excitability of the motor eloquent areas in patients with diffuse gliomas.