Abstract
Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al. developed a mathematical model to assess some features of this altered metabolism. Here, we take a broader look at the regulation of energy metabolism in cancer cells, considering their anabolic as well as catabolic needs.See research article: http://www.biomedcentral.com/1752-0509/4/58/
Highlights
Cancer cells have different metabolic requirements from their normal counterparts
Understanding the consequences of this differential metabolism requires a thorough analysis of glucose metabolism and its relation to energy production in cancer cells
Cells that achieve high rates of aerobic glycolysis often show relatively small changes in the rate of oxygen consumption in response to changes in glucose uptake; that is, oxidative catabolic flux through the Krebs cycle leading to mitochondrial ATP generation is somewhat independent of glucose metabolism [3]
Summary
Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. Understanding the consequences of this differential metabolism requires a thorough analysis of glucose metabolism and its relation to energy production in cancer cells.
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