Abstract

Subcellular localization of the copper homeostasis proteins ATP7A and ATP7B, which are assumed to be involved in the intracellular transport of cispla-tin, has been investigated in the A2780 human ovarian carcinoma cell line and its cisplatin-resistant variant A2780cis cell line. In the sensitive cells, both proteins are localized in the trans-Golgi network, whereas they are sequestrated in more peripherally located vesicles in the resistant cells. Changes in subcellular localization of ATP7A and ATP7B may facilitate sequestration of cisplatin in vesicular structures, which may in turn prevent drug binding to genomic DNA and thereby contribute to cisplatin resistance.KeywordsCisplatin resistanceATP7AATP7BSequestration

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