Abstract
Introduction: Subclinical hypothyroidism refers to thyroid hormone deficiency in patients who have no apparent clinical features. Both iron deficiency anemia and subclinical hypothyroidism, due to their high prevalence and close interrelation, are significant clinical problems.
 Aims and Objectives: Association of subclinical hypothyroidism and disordered iron metabolism was studied so that better management of iron deficiency could be advised in these patients.
 Materials and Methods: 150 newly diagnosed subclinical hypothyroid patients and 150 healthy euthyroid controls were included. Total T3, total T4, TSH, iron, TIBC, transferrin and ferritin were measured. Data was analysed by student‘t’ test and Person’s formula.
 Results: Mean total T3, total T4, iron, TIBC, transferrin and ferritin values of study group were lower than that of control group (p < 0.05). Mean TSH values of study group was higher than that of control group (p < 0.05). Total T4 and T3 were positively correlated with transferrin (p < 0.05). The patients of subclinical hypothyroidism had altered iron metabolism.
 Conclusion: Decreased iron profile in subclinical hypothyroidism was significantly high. It was suggestive to regularly investigate iron profile for early detection and its early management in case of subclinical hypothyroidism.
 Keywords: Subclinical Hypothyroidism, Serum Iron, TIBC, Ferritin, Transferrin
Highlights
Introduction: Subclinical hypothyroidism refers to thyroid hormone deficiency in patients who have no apparent clinical features
Subclinical hypothyroidism refers to biochemical evidence of thyroid hormone deficiency in patients who have few or no apparent clinical features of hypothyroidism [1]
Many studies have attempted to study the relationship between subclinical hypothyroidism and iron deficiency anemia, but due to limited number of large cohort studies, a definitive status of this entity is still eluting the clinicians posing problems in management
Summary
Subclinical hypothyroidism refers to thyroid hormone deficiency in patients who have no apparent clinical features. Results: Mean total T3, total T4, iron, TIBC, transferrin and ferritin values of study group were lower than that of control group (p < 0.05). Subclinical hypothyroidism refers to biochemical evidence of thyroid hormone deficiency in patients who have few or no apparent clinical features of hypothyroidism [1]. It is called as mild hypothyroidism; early thyroid failure, preclinical hypothyroidism or decreased thyroid reserve and is a condition characterized by elevated serum TSH in the setting of normal total or free thyroxine (T4) concentration in serum [2]. In areas of relative iodine deficiency, there is an increased prevalence of goiter and, when deficiency is severe, hypothyroidism and cretinism [4]
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