Abstract

Decline in self-awareness (anosognosia) is a prevalent early symptom of Alzheimer's disease (AD). The integrity of the functional hubs of the default mode network (DMN) has been heavily implicated in retained self-awareness abilities in AD patients. Moreover, an early breakdown of this network has been found to be a hallmark feature in the clinical profile of AD. However, the interplay among other large-scale brain networks in support of cognitive awareness in early-AD remains poorly understood.

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