Abstract
Similar to the Warburg effect in cancer cells, altered energy metabolism with a shift toward increased reliance on glycolysis for energy production leading to a buildup of lactate and increased acidity has been demonstrated in schizophrenia brain. In cancer cells, this has been shown to lead to a compensatory redistribution of Na+/H+ Exchanger (NHE) 6 from early endosomes to the plasma membrane with a resultant overacidification of endosomes. We are investigating whether similar redistribution of organellar NHEs may occur in schizophrenia brain. In cancer cells, the redistribution of NHE6 is mediated by increased interactions with the scaffolding protein RACK1. We have not seen significant changes in total levels of NHE6/8/9 in postmortem schizophrenia dorsolateral prefrontal cortex (DLPFC), so here we measured interactions between these proteins and RACK1.
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