Abstract
The global incidence of type-2-diabetes (T2D) is continuing to rise and of greatest importance for health economics. The underlying molecular mechanisms of T2D are not sufficiently understood, and effective therapies are thus lacking. Genetic factors including single nucleotide polymorphisms (SNPs) influence insulin sensitivity. Moreover, epigenetic mechanisms are relevant for T2D affecting expression of genes involved in glucose and fatty acid metabolism in obese humans and mice. This study aims at studying epigenetically regulated genes in liver of obese subjects to identify pathways which contribute to the manifestation of insulin resistance or sensitivity independent of obesity.
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