Abstract
Background and Purpose: Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which including VBM studies of patients with T1DM was conducted.Materials and Methods: The gray matter volume alterations in patients with T1DM was estimated by using the software seed-based d mapping. Meantime, the meta-regression was applied to detect the effects of some demographics and clinical characteristics.Results: Six studies were finally included, which with 6 datasets comprising 414 T1DM patients and 216 healthy controls. The pooled meta-analyses detected that patients with T1DM showed robustly increased gray matter volume in the left dorsolateral superior frontal gyrus and middle frontal gyrus and a decreased gray matter volume in the right lingual gyrus, cerebellum, precuneus, the left inferior temporal gyrus, and middle temporal gyrus. The meta-regression showed that the mean age, the female patient's ratio, duration of illness and HbAlc% for T1DM patients were not linearly related with gray matter alterations.Conclusion: This meta-analysis demonstrates that gray matter volume decreases in T1DM patients were mainly locates in the cortical regions and cerebellum.
Highlights
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease which often occurs in children [1]
Which found that the gray matter volume increased significantly in the left dorsolateral superior frontal gyrus (SFG) and middle frontal gyrus (MFG) and decreased significantly in the right lingual gyrus, cerebellum, precuneus, and the left inferior temporal gyrus (ITG) in all but one Studies Included in the Meta-Analyses
The T1DM and control groups had no significant difference in age or sex in each study
Summary
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease which often occurs in children [1]. During the past few years, the amount of T1DM patients has sharply increased in lots of countries [2]. Glucose dysregulation in T1DM can lead to severe complications, including neuropathies, which has been reported to increase the incidence of cognitive deficits and psychological dysfunction [3, 4]. An important tool brain imaging is always being used to explore the mechanisms linking T1DM and cognitive dysfunction. Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). The quantitative meta-analysis which including VBM studies of patients with T1DM was conducted
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