Abstract
The recent increase in obesity and diabetes incidence is too rapid to be entirely accounted for by dietary and exercise components alone, raising the possibility that environmental factors also contribute to this epidemic. It has been proposed that exposure to industrial chemicals possessing endocrine-disrupting activity causes changes in metabolic homeostatic systems during embryonic development which could lead to development of adult obesity. This chapter reviews evidence for the effects of potential endocrine disruptors on homeostatic systems regulating insulin secretion and glucose uptake. The effects of endocrine disruptors on adipocyte differentiation and glucose uptake are also considered. Alterations in these pathways could lead to enhanced weight gain and eventually, diabetes in adults.KeywordsAdipocyteEDCEndocrine-disrupting chemicalsGlucose homeostasisInsulinObesity
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