Altered Functional Connectivity in the Resting State Neostriatum After Complete Sleep Deprivation: Impairment of Motor Control and Regulatory Network.

Haiteng Wang,Jialu Li,Lingjing Zeng,Yongcong Shao,Ke Yu,Ziyi Peng,Jianlin Qi,Tianyi Yang,Cimin Dai,Weiwei Fu

doi:10.3389/fnins.2021.665687

Abstract

Sleep loss not only compromises individual physiological functions but also induces a psychocognitive decline and even impairs the motor control and regulatory network. In this study, we analyzed whole-brain functional connectivity changes in the putamen and caudate nucleus as seed points in the neostriatum after 36 h of complete sleep deprivation in 30 healthy adult men by resting state functional magnetic resonance imaging to investigate the physiological mechanisms involved in impaired motor control and regulatory network in individuals in the sleep-deprived state. The functional connectivity between the putamen and the bilateral precentral, postcentral, superior temporal, and middle temporal gyrus, and the left caudate nucleus and the postcentral and inferior temporal gyrus were significantly reduced after 36 h of total sleep deprivation. This may contribute to impaired motor perception, fine motor control, and speech motor control in individuals. It may also provide some evidence for neurophysiological changes in the brain in the sleep-deprived state and shed new light on the study of the neostriatum in the basal ganglia.

Highlights

Total sleep deprivation (TSD) refers to a physiological state of less than 4 h of continuous sleep for at least 24 h
We performed the procedure described in sections “MRI Data Preprocessing” and “rs-functional magnetic resonance imaging (fMRI) Data Functional Connectivity Analysis” for each subject’s data, performing correlation analysis between the blood oxygenation level dependent (BOLD) signal from each regions of interest (ROIs) and whole brain voxels with paired samples t-tests
Results of whole-brain functional connectivity (FC) patterns in the bilateral putamen and caudate nucleus before and after sleep deprivation are detailed in Figures 1–4 and Tables in Supplementary Material

Summary

Introduction

Total sleep deprivation (TSD) refers to a physiological state of less than 4 h of continuous sleep for at least 24 h. Fine motor control is a high-level cognitive function of humans, which belongs to the TSD Impairs Motor Control category of voluntary movement, and occurs throughout the whole process of human daily life and social activities, such as reading, writing, speech, working, and some sports (Stippich et al, 2007; Bracci et al, 2012; Hao et al, 2016). With the rapid development of medical imaging, functional magnetic resonance imaging (fMRI) techniques have provided further insights into the in vivo study of neural mechanisms, as well as into the imaging mechanism of fine motor control (Lee et al, 2010; Plow et al, 2010). Rs-fMRI has obvious advantages for studying brain spontaneous activity, functional connectivity among various brain regions, development and plasticity of brain function, and neuropsychiatric disorders, and is a recent focus of research on brain function (Friston, 2004; Zhu et al, 2020)

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