Altered functional connectivity in individuals with loss of control eating.

Abstract

Event Abstract Back to Event Altered functional connectivity in individuals with loss of control eating. Leora Benson1*, Karol Osipowicz1, Fengqing (Zoe) Zhang1 and Michael R. Lowe1 1 Drexel University, United States Eating disorders (ED) are difficult to treat. A better understanding of ED etiology would help inform treatment and prevention. Loss of control eating (LOC), a sense of not being able to stop or control eating, accompanies binge eating in individuals with bulimia nervosa (BN) or binge eating disorder (BED). Additionally, LOC can be an early marker of eating-related psychopathology in children. Few studies have examined brain network alterations related to LOC. A better understanding of the early neural-behavioral correlates of eating disorder symptoms can help identify who might be at risk of future disease development or increased severity. This study examined whole brain functional connectivity using resting state fMRI in individuals with LOC. The sample included male and female individuals who did (n=49) or did not (n=49) endorse LOC (matched for age and gender), assessed by a yes or no response to the diagnostic question, “Has there been a time when your eating was out of control?”. Participants were aged 10-20 years and part of the 1445 Philadelphia Neurodevelopmental Cohort that underwent neuroimaging. Individuals reporting LOC (vs. no LOC) demonstrated disturbances in resting state functional connectivity between several frontoparietal regions and regions associated with the default mode network, visual processing (e.g. lateral occipital gyrus), and appetitive behavior (e.g. frontal operculum). These findings are consistent with the idea that individuals with LOC have dysfunction of self-regulation over their intrinsic state and sensory processing. These findings provide the first insights into the neural basis of LOC individuals’ difficulty controlling appetitive drive and their poor control and distorted perceptions of the state of their body; traits that often characterize individuals with eating disorders. Keywords: functional connectivity, resting state fMRI, Eating Disorders, loss of control (LOC), eating-related psychopathology Conference: 2nd International Neuroergonomics Conference, Philadelphia, PA, United States, 27 Jun - 29 Jun, 2018. Presentation Type: Poster Presentation Topic: Neuroergonomics Citation: Benson L, Osipowicz K, Zhang F and Lowe MR (2019). Altered functional connectivity in individuals with loss of control eating.. Conference Abstract: 2nd International Neuroergonomics Conference. doi: 10.3389/conf.fnhum.2018.227.00112 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 13 Apr 2018; Published Online: 27 Sep 2019. * Correspondence: Ms. Leora Benson, Drexel University, Philadelphia, United States, leorabenson@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Leora Benson Karol Osipowicz Fengqing (Zoe) Zhang Michael R Lowe Google Leora Benson Karol Osipowicz Fengqing (Zoe) Zhang Michael R Lowe Google Scholar Leora Benson Karol Osipowicz Fengqing (Zoe) Zhang Michael R Lowe PubMed Leora Benson Karol Osipowicz Fengqing (Zoe) Zhang Michael R Lowe Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.