Abstract

BackgroundFunctional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the altered functional network with the identified brain regions. This may be an effective assessment strategy for headache research. This study is to investigate the RSFC architecture changes of the brain in the patients with medication overuse headache (MOH) using FCD and RSFC methods.Methods3D structure images and resting-state functional MRI data were obtained from 37 MOH patients, 18 episodic migraine (EM) patients and 32 normal controls (NCs). FCD was calculated to detect the brain regions with abnormal functional activity over the whole brain, and the seed-based RSFC was performed to explore the functional network changes in MOH and EM.ResultsThe decreased FCD located in right parahippocampal gyrus, and the increased FCD located in left inferior parietal gyrus and right supramarginal gyrus in MOH compared with NC, and in right caudate and left insula in MOH compared with EM. RSFC revealed that decreased functional connectivity of the brain regions with decreased FCD anchored in the right dorsal-lateral prefrontal cortex, right frontopolar cortex in MOH, and in left temporopolar cortex and bilateral visual cortices in EM compared with NC, and in frontal-temporal-parietal pattern in MOH compared with EM.ConclusionsThese results provided evidence that MOH and EM suffered from altered intrinsic functional connectivity architecture, and the current study presented a new perspective for understanding the neuromechanism of MOH and EM pathogenesis.

Highlights

  • Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the altered functional network with the identified brain regions

  • Further functional connectivity using resting-state functional MRI demonstrated that altered functional connectivity was revealed in medication overuse headache (MOH), and suggested that MOH is associated with intrinsic brain network changes rather with macrostructural changes [2]

  • Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) score showed higher in MOH than that in episodic migraine (EM) and normal controls (NC), and Montreal Cognitive Assessment (MoCA) score presented lower in MOH than that in EM and NC (P < 0.05)

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Summary

Introduction

Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the altered functional network with the identified brain regions. This may be an effective assessment strategy for headache research. Previous studies demonstrated that functional and structural changes were identified in MOH [2, 4–6], functional connectivity density (FCD) over the whole brain and functional. Further functional connectivity using resting-state functional MRI (rs-fMRI) demonstrated that altered functional connectivity was revealed in MOH, and suggested that MOH is associated with intrinsic brain network changes rather with macrostructural changes [2].

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