Abstract
Healthy adults (n=51) over the age of 40 consumed a wash‐in diet for 3 d followed by an intervention diet with 300 g blackberries or an isocaloric gelatin control at breakfast for 6 d. Metabolite profiling was conducted by Metabolon using GC/MS and LC/MS/MS platforms using fasting plasma samples from d 9. Following log transformation and imputation with minimum observed values, Welch's two‐sample t‐test was used to identify biochemicals that differed significantly between experimental groups. Blackberry intake compared to control revealed metabolite changes that reflect likely changes in gut metabolism (phenol sulfate), TCA cycle energetics (α‐ketoglutarate), the pentose phosphate pathway (threitol), and metabolism of benzoate (phenol sulfate), isoleucine (3‐hydroxy‐2‐ethylpropionate), medium‐chain fatty acids (undecanoate), collagen (trans‐4‐hydroxyproline), choline (betaine), and xanthine (3‐methylxanthine) and decreased fucose. Methyl‐beta‐glucopyranoside, a likely anthocyanidin metabolite, and one unknown compound were identified as potential markers of compliance for blackberry intake. Levels of these markers, however, did not correlate with levels of other altered metabolites. Support: NIH/USDA
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