Abstract
An increase in the susceptibility to drugs is known to occur with advanced age. Several possible explanations for this phenomenon exist, but the exact cause has not been determined. Aryl hydrocarbon hydroxylase (AHH), 7-ethoxycoumarin O-deethylase (ECD) and aniline hydroxylase activities of hepatic and extrahepatic tissues as well as hepatic cytochrome P-450 content of female Swiss Webster mice at 1, 3, 6, 9, 12, 15 and 18 months of age were examined. AHH activity in liver and intestine reached a maximum at 6 mo. of age and began to decline thereafter. No change in pulmonary AHH activity was observed with age. ECD activity in liver as well as lungs was maximal at 6 mo. of age and decreased thereafter. Hepatic aniline hydroxylase activity exhibited over a 700% increase between one to six mo. of age, and declined by approximately 52% by 15 mo. of age as compared to peak activity. Hepatic cytochrome P-450 content was highest at 3 mo. of age and significantly decreased by 12 mo. The results demonstrate that decreases in microsomal mixed function monooxygenase activities do occur with advanced age and may contribute to a decreased rate of metabolism and increased susceptibility to drugs and other foreign chemicals with age.
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