Altered Dopamine Activity after Recovery from Restricting-Type Anorexia Nervosa

Abstract

When ill, women with eating disorders have disturbances of mood and behavior and alterations of catecholamine activity. It is not known whether these alterations are cause or consequence of pathological eating behaviors. To avoid confounding effects of pathologic eating behavior, we studied women who were recovered (>1 year, normal weight, regular menstrual cycles, no restricting eating pattern, no bingeing or purging) from anorexia nervosa (AN) and bulimia nervosa (BN) compared to healthy control women. Recovered AN women had significantly lower height-adjusted weight than did recovered BN women. CSF HVA (pmol/ml ± SD), a major metabolite of dopamine, was significantly lower (p < .02) in six restricting-type AN women (131 ± 49) compared to 19 BN women (216 ± 73) and at a trend (p < .08) less than 13 bulimic-type AN women (209 ± 53, p < .06) and 18 control women (202 ± 57, p < .08). These four groups had similar values for CSF MHPG, a norepinephrine metabolite. Dopamine neuronal function has been associated with motor activity, reward, and novelty seeking. These behaviors are altered in restricting-type AN compared to other eating disorder subtypes. A trait-related disturbance of dopamine metabolism may contribute to a vulnerability to develop this sub-type of eating disorder.