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Abstract
ObjectivesThe main objective of this study was to determine whether the DNA methylation profile of children born to mothers with rheumatoid arthritis (RA) is different from that of children born...
Highlights
ObjectivesThe main objective of this study was to determine whether the DNA methylation profile of children born to mothers with rheumatoid arthritis (RA) is different from that of children born to mothers from the general population
The first model was created to compare the blood samples from the FEtal Programming in Rheumatoid Arthritis (FEPRA) study with the blood samples of the Generation R Study to determine whether the DNA methylation profile of children born to mothers with rheumatoid arthritis (RA) was different from that of children born to mothers from the general population
These two genes were the nearest genes to those CpGs.[45]. Both CpGs were hypermethylated in the children born to mothers with RA and were associated with decreased expression of COPZ2 and ADD2 in the BIOS expression quantitative trait methylation (eQTM) lookup browser. This is the first study investigating the differences in DNA methylation of children born to mothers with RA compared with children born to mothers from the general population
Summary
The main objective of this study was to determine whether the DNA methylation profile of children born to mothers with rheumatoid arthritis (RA) is different from that of children born to mothers from the general population. We aimed to determine whether any differences in methylation are associated with maternal RA disease activity or medication use during pregnancy. Conclusions DNA methylation at 147 CpGs differed between children born to mothers with RA and children born to mothers from the general population. It remains unknown whether the identified associations are causal, and if so whether they are caused by the disease or treatment. More research, including replication of these results, is necessary in order to strengthen the relevance of our findings for the later-life health of children born to mothers with RA
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