Altered cortical activity in patients with lower limb amputation based on EEG microstate.

Conghui Wei,Jun Luo,Xinying Shan,Shaowen Liu

doi:10.31083/j.jin2004100

Conghui Wei, Jun Luo + Show 2 more

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https://doi.org/10.31083/j.jin2004100

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Abstract

Previous studies have revealed significant changes in electroencephalogram (EEG) microstates in neuropsychiatric diseases, including schizophrenia, depression, and dementia. To explore the resting-state EEG microstate with amputation, we collected the EEG datasets from 15 patients with lower limb amputation and 20 healthy controls. Then, we analyzed the parameters of four classical EEG microstates (A-D) between the two groups. Specifically, the parameters were statistically analyzed, including duration, occurrence rate, time coverage, and transition rate. According to the results, the duration of microstate C (t = 2.95, p = 0.005) in the lower limb amputation group was significantly smaller compared with the control group, while the occurrence rate of microstate B (t = -2.22, p = 0.03) and D (t = -3.35, p = 0.002) were significantly larger in the lower limb amputation group. In addition, the transition rate of microstate differed significantly in AC, CA, DB between the two groups. Our results implied: (1) amputation has changed the resting-state EEG microstate; (2) EEG microstate analysis can be an approach to explore the alteration of cortical function.

Highlights

According to the site, amputation can be classified into upper limb amputation and lower limb amputation
The final microstate topographic maps of the lower limb amputation (LLA) and healthy controls (HC) groups are shown in Fig. 1 (Ref. [30])
The alteration in the spatial distribution of primary neuronal sources indicates a significant difference in the map configuration between the LLA group and healthy controls for microstate C and D

Summary

Introduction

Amputation can be classified into upper limb amputation and lower limb amputation. Studies have reported brain reorganization in the primary sensorimotor cortex (SMC) [2, 3]. Compared with healthy controls, there was a higher activity level of the contralateral primary motor cortex (M1) in the upper limb amputees, especially of the face representation within SMC [5, 6]. An enhanced connection was observed in the primary and secondary somatosensory cortex areas and the primary and premotor regions within the cerebral hemispheres. These structural and functional reorganizations in inter-hemispheric and intra-hemispheric sensory and motor cortex areas improved our understanding of brain plasticity after amputation [7]. These cortical reorganizations were interpreted as brain adaptation to the loss of peripheral sensory and motor input [8]

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