Abstract
Reemergence of carcinomas following chemotherapy and/or radiotherapy is not well understood, but a recent study in BMC Cancer suggests that resistance to apoptosis resulting from altered cell cycle regulation is crucial.See research article: http://biomedcentral.com/1471-2407/10/166
Highlights
Reemergence of carcinomas following chemotherapy and/or radiotherapy is not well understood, but a recent study in BMC Cancer suggests that resistance to apoptosis resulting from altered cell cycle regulation is crucial
Subpopulations with increased apoptotic resistance Understanding the mechanisms underpinning resistance to apoptosis following chemo- or radiotherapy has been prompted by the promise that this could lead to a new generation of therapeutic approaches
New findings reported in BMC Cancer [5] reveal that altered cell cycle regulation could have a role in apoptotic resistance in at least some CSCs
Summary
Reemergence of carcinomas following chemotherapy and/or radiotherapy is not well understood, but a recent study in BMC Cancer suggests that resistance to apoptosis resulting from altered cell cycle regulation is crucial. Subpopulations with increased apoptotic resistance Understanding the mechanisms underpinning resistance to apoptosis following chemo- or radiotherapy has been prompted by the promise that this could lead to a new generation of therapeutic approaches. New findings reported in BMC Cancer [5] reveal that altered cell cycle regulation could have a role in apoptotic resistance in at least some CSCs. Epithelial tumors are the most commonly diagnosed cancer type [6] and are a high priority in terms of therapeutic development.
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