Altered brain responses to emotional auditory stimuli in AVH subjects: an fMRI study

Abstract

Purpose: Auditory verbal hallucinations (AVH) are a frequently occurring phenomenon in which subjects hear verbal sounds in the absence of any external stimuli. The prevalence of auditory hallucinations in schizophrenia has been revealed in many studies. Healthy subjects may also experience auditory hallucinations without accompanying psychological or neurological disorders, and in rare cases they seek clinical assistance for this emotionally disturbing condition. The aim of this study was to investigate the neural basis of emotional disturbance in auditory hallucinating subjects who do not suffer from any psychological or neurological disorder. Materials and Methods: Fourteen subjects suffering from auditory hallucinations and 15 age- and sex-matched healthy controls were recruited in this study. All participants underwent fMRI in two experimental sessions. In the first experimental session, all participants from both groups listened to pleasant auditory stimuli. In the second session, both groups listened to unpleasant auditory stimuli. The auditory stimuli were obtained from the International Affective Digitized Sounds (IADS). Results: Compared with the healthy control group, AVH subjects exhibited significantly increased activation in limbic, auditory, and frontal regions. Conclusion: Current results suggest that AVH may induce functional reorganization in emotion-related brain regions.