Abstract
ObjectiveTo investigate the differences in insulin sensitivity and glucose tolerance among women with spinal cord injury (SCI) in comparison to their able‐bodied (AB) counterparts after adjusting for differences in body composition.DesignCross‐sectional study. Following an overnight fast, each participant consumed a 75‐g glucose solution for oral glucose tolerance test (OGTT). Blood glucose, insulin, and C‐peptide concentrations were analyzed before and 30‐, 60‐, and 120‐minute post‐consumption. Insulin sensitivity index (ISI) was estimated using the Matsuda index. Percentage fat mass (%FM) and relative skeletal muscle index (RSMI) were estimated using data from dual‐energy X‐ray absorptiometry. Visceral fat (VF) was estimated using computerized tomography (CT). Outcome measures were compared among groups using ANCOVA with %FM, VF and RSMI as covariates.SettingResearch UniversityParticipantsWomen with SCI (tetraplegia: n=8; paraplegia: n=14) and their body mass index‐and age‐matched AB counterparts (n=20).InterventionsNot applicable.ResultsAt fasting, there was no difference in glucose homeostasis (glucose, insulin, and C‐peptide concentrations) among 3 groups of women. In contrast, glucose, insulin, and C‐peptide concentrations at OGTT 120 min were higher in women with tetraplegia vs. women with paraplegia and AB women (P < 0.05, adjusted for RMSI and %FM). In addition, women with tetraplegia had lower ISI (P < 0.05, adjusted for RMSI and %FM) vs. AB women. These differences remained after adjusting for VF and RSMI.ConclusionOur study confirms that while alterations in body composition may contribute to metabolic deficits in women with SCI, it does not fully account for impaired glucose homeostasis in women with tetraplegia.Support or Funding InformationThis work was supported by the NIH under Grant K12 HD001402/HD/NICHD NIH (Chen), M01 RR000032/RR/NCRR NIH (Chen), NIDLRR – DHHS‐Administration for Community Living Sponsor award 02‐90SI501901 The University of Alabama at Birmingham Spinal Cord injury Model System (McLain).This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
