Altered blood oxidative stress biomarkers in association with canine parvovirus enteritis

Abstract

Canine parvovirus (CPV-2), a member of Parvoviridae, mainly affects puppies and it is a major cause of vomiting and diarrhea in canine; sometimes, it has fatal outcomes. This study aims to scrutinize the alterations in hematology as well as oxidative stress biomarkers in association with CPV-2 infection in puppies. The present study was applied on 22 dogs with different breeds, both sexes, and different age, divided into 8 healthy dogs enrolled as a control group and 14 dogs with clinical signs consistent with CPV-2 infection. Blood samples were withdrawn from each animal from cephalic vein for complete blood count using automated hematology analyzer and to estimate level of oxidant biomarkers (MDA and H2O2) and antioxidant biomarkers (SOD, GPX, catalase, Zn, Cu, and iron), with cortisol level. The elevation of MDA, H2O2, SOD, and GPX and decrease of catalase, Zn, Cu, and iron were recorded in diseased dogs compared with those in control dogs. In conclusion, dogs with CPV-2 infection, MDA, and H2O2 elevation contributed to oxidative stress state and alteration in antioxidant biomarkers as SOD, GPX, catalase, and trace minerals as Zn, Cu, and iron to counteract the expected damage of cells were recorded. Based on these findings, antioxidant supplementation might bolster body defense mechanism and decreases stress condition.