Altered attentional processing of happy prosody in schizophrenia

Abstract

BackgroundAbnormalities in emotional prosody processing have been consistently reported in schizophrenia. Emotionally salient changes in vocal expressions attract attention in social interactions. However, it remains to be clarified how attention and emotion interact during voice processing in schizophrenia. The current study addressed this question by examining the P3b event-related potential (ERP) component. MethodThe P3b was elicited with a modified oddball task, in which frequent (p = .84) neutral stimuli were intermixed with infrequent (p = .16) task-relevant emotional (happy or angry) targets. Prosodic speech was presented in two conditions - with intelligible (semantic content condition - SCC) or unintelligible semantic content (prosody-only condition - POC). Fifteen chronic schizophrenia patients and 15 healthy controls were instructed to silently count the target vocal sounds. ResultsCompared to controls, P3b amplitude was specifically reduced for happy prosodic stimuli in schizophrenia, irrespective of semantic status. Groups did not differ in the processing of neutral standards or angry targets. DiscussionThe selectively reduced P3b for happy prosody in schizophrenia suggests top-down attentional resources were less strongly engaged by positive relative to negative prosody, reflecting alterations in the evaluation of the emotional salience of the voice. These results highlight the role played by higher-order processes in emotional prosody dysfunction in schizophrenia.