Abstract
Post-traumatic stress disorder (PTSD) affects more than 30% of Veterans returning from modern wars. Unfortunately, PTSD is often resistant to current treatments, such as SSRIs and exposure therapy, that target fear neurocircuitry. One possible explanation is that the neurobiology of PTSD extends beyond fear neurocircuitry and includes alterations in neural circuits that underlie anxiety. In this study, we investigated the bed nucleus of the stria terminalis (BNST), a brain region implicated in the anxiety, hypervigilance and threat anticipation response that is characteristic of PTSD.
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