Abstract
Mounting evidence suggests that attention deficit/hyperactivity disorder (ADHD) is related with abnormal anatomical asymmetry in some brain regions, such as basal ganglia.However, few cross-sectional studies have examined the abnormalities of anatomical asymmetry in whole brain of ADHD. Thus this cross-sectional study was to explore the anatomical asymmetry in whole brain of ADHD with optimized voxel-based morphometry (OVBM). Twenty-five boys with ADHD and 27 age and gender-matched controls were recruited. All participants were right-handed. The grey matter concentration of each voxel was calculated with OVBM. A statistical evaluation of grey matter asymmetry was then conducted on normalized grey matter images and their flipped counterparts. One-sample t-test revealed that the whole-brain anatomical asymmetry pattern was similar in two groups. Through group comparisons, ADHD showed reversed left-greater-than-right asymmetry in superior and middle frontal gyri versus controls. Anatomical asymmetry of prefrontal cortex is abnormal in children with ADHD. And abnormal anatomical asymmetry may play an important role in the pathophysiology of ADHD.
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