Abstract
Gut microbiota played an important role in systemic lupus erythematosus (SLE) and glucocorticoids were prone to cause alterations in gut microbiota. This study addressed the effect of bromofuranone on the treatment of SLE with prednisone, since bromofuranone could regulate gut microbiota by inhibiting the AI-2/LuxS quorum-sensing. Remarkably, bromofuranone did not alleviate lupus but promoted the efficacy of prednisone in the treatment of lupus. The alterations in the gut microbiota, including decreased Mucispirillum, Oscillospira, Bilophila and Rikenella, and increased Anaerostipes, were associated with prednisone treatment for SLE. In addition, the increase of Lactobacillus, Allobaculum, Sutterella, and Adlercreutzia was positively associated with the bromofuranone-mediated promotion for the treatment of lupus. This was the first study demonstrating that the efficacy of glucocorticoids could be affected by the interventions in gut microbiota.
Highlights
Systemic lupus erythematosus was a severe multisystemic autoimmune disease characterized by the loss of tolerance to autoantigens along with the production of antinuclear antibodies
The roles of the gut microbiota in systemic lupus erythematosus (SLE) had become increasingly apparent and studies had indicated that the changing of gut microbiota could affect lupus activity (Cuervo et al, 2015; Mu et al, 2017)
In MRL/lpr mice, the alterations of gut microbiota were closely related to the efficacy of prednisone
Summary
Systemic lupus erythematosus was a severe multisystemic autoimmune disease characterized by the loss of tolerance to autoantigens along with the production of antinuclear antibodies. The etiology of SLE had been related to genetic, environmental, hormonal, and immunological factors (Tsokos, 2011). A strong relationship between the gut microbiota and SLE had been demonstrated in SLE patients (Hevia et al, 2014; He et al, 2016) and lupus mice (Zhang et al, 2014; Luo X.M. et al, 2018). There was evidence that the gut microbiota played an important role in the regulation of antinuclear antibodies, TLR2/IL-17, IFN-γ, TLR4, Th17/IgM, etc. The gut microbiota could affect the progression of SLE
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