Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus.

Zhijun Xie,Haichang Li,Tiejuan Shao,Chengping Wen,Zhixing He

doi:10.1186/s13099-016-0146-9

Zhijun Xie, Haichang Li

Open Access

https://doi.org/10.1186/s13099-016-0146-9

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Journal: Gut pathogens	Publication Date: Dec 1, 2016
Citations: 180	License type: cc-by

Affiliation: Zhejiang Chinese Medical University

Abstract

BackgroundSystemic lupus erythematosus (SLE) in patients from Spain is associated with intestinal dysbiosis. This study explores whether the alteration of the gut microbiome in SLE patients from China is consistent with the intestinal dysbiosis of SLE patients from Spain.ResultsThe depletion of Firmicutes and the enrichment of Bacteroidetes in SLE patients from China were consistent with the SLE patients from Spain. Furthermore, we found that nine genera of gut microbiota were SLE-related microorganisms in Chinese subjects. Genera Rhodococcus, Eggerthella, Klebsiella, Prevotella, Eubacterium, Flavonifractor and Incertae sedis were significantly enriched, while genera Dialister and Pseudobutyrivibrio were significantly depleted in SLE patients. Receiver operating characteristic analysis indicated that the nine genera have the potential to distinguish SLE patients from healthy controls.ConclusionsComparing the dysbiosis of the gut microbiome among SLE patients from China or Spain, may indicate that the gut microbiome profiles of SLE patients are more influenced by disease than ethnicity.

Highlights

Systemic lupus erythematosus (SLE) in patients from Spain is associated with intestinal dysbiosis
PD_whole_tree, observed species, Singles and Doubles were significantly higher in healthy controls than in SLE patients, but there was no difference in Shannon and Simpson
The above results indicate that lower diversity, richness and rare Operational Taxonomic Units (OTUs) of gut microbiome existed in SLE patients, but the evenness of the gut microbiome could not differentiate SLE patients from healthy controls

Summary

Introduction

Systemic lupus erythematosus (SLE) in patients from Spain is associated with intestinal dysbiosis. This study explores whether the alteration of the gut microbiome in SLE patients from China is consistent with the intestinal dysbiosis of SLE patients from Spain. Increased evidence indicates that intestinal dysbiosis is associated with human diseases, such as cancer [4], liver cirrhosis [5], and autoimmune diseases [6, 7]. Systemic lupus erythematosus (SLE), a complex autoimmune disease characterized by its higher frequency in women, is associated with the gut microbiome. The SLE patients from Spain were characterized by increased Bacteroidetes levels and a lower Firmicutes/ Bacteroidetes ratio [8]. The gut microbiome can serve as new biomarkers or therapy for SLE

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