Alterations of Serum Biochemical and Urinary Parameters in a Canine Population before and after Intravenous Contrast Administration.

Federica Cagnasso,Barbara Miniscalco,Paola Gianella,Ilaria Lippi,Silvia Roncone,Alberto Valazza,Renato Zanatta,Barbara Bruno,Antonio Borrelli,Claudio Bellino

doi:10.3390/vetsci8080146

Federica Cagnasso, Barbara Miniscalco + Show 8 more

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https://doi.org/10.3390/vetsci8080146

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Abstract

Intravenous iodinated contrast (IVIC) medium is routinely administered to dogs. Scattered information exists regarding the serum biochemical or urinary profiles associated with the administration of IVIC in dogs. The aim of the study was to describe, compare, and discuss from the perspective of previous studies the alterations in serum biochemical and urinary parameters before (T0) and within one week (T1) of the IVIC administration during routine computed tomography (CT) scan evaluation of 22 dogs. Mature dogs presenting for CT scan evaluation for preoperative oncology staging/surgical planning were included. T1 evaluation was performed within one week of IVIC administration. Statistically significant differences in serum total protein, albumin, chloride, calcium, and phosphorus concentrations, urine protein to creatinine ratio, and urine specific gravity were found between T1 and T0. At T1, the serum creatinine concentration was within reference ranges in all dogs but one. An increase in the urine protein to creatinine ratio was observed in four samples, one of which was non-proteinuric at T0. Changes in biochemistry and urine parameters between T0 and T1 were not considered clinically significant.

Highlights

Iodinated contrast media are among the most frequently used contrast agents in medical practice [1]
5 years, requiring a computed tomography (CT) scan evaluation for preoperative oncologic staging/surgical planning, being unaffected by acute kidney injury, and being able to return for blood and urine reevaluation within 1 week following Intravenous iodinated contrast (IVIC) administration
This study evaluated for alterations in serum biochemical and urinary parameters before and within 1 week after IVIC administration during CT scanning under general anesthesia in a selected canine population

Summary

Introduction

Iodinated contrast media are among the most frequently used contrast agents in medical practice [1]. Mild to severe adverse reactions, contrast-induced acute kidney injury (CI-AKI), have been observed in humans [2,3,4]. In human medicine, CI-AKI has been defined as an increase in serum creatinine concentration by. The 2011 KDIGO released guidelines with a new CI-AKI definition, namely an increase in serum creatinine concentration by ≥0.3 mg/dL (26.5 μmol/L) within. The IRIS group has recommended a 5-grade system of disease severity for AKI, which is based on the serum creatinine concentration. It does not describe a steady-state condition, the renal function and the serum creatinine varying continuously in AKI [9]. An advanced chronic kidney disease contributes to a threefold increase in the risk of CI-AKI development [11]

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