Alterations of plasma non-enzyme antioxidants levels in chronic schizophrenic patients with tardive dyskinesia

Abstract

Objective To investigate the plasma non-enzyme antioxidants levels in chronic schizophrenic patients with tardive dyskinesia (TD). Methods The plasma levels of albumin (Alb), bilirubin (Bil) and uric acid (UA) in schizophrenic patients with TD (TD group，n=60) and without TD (non-TD group，n=60) and healthy volunteers (control group，n=45) were assayed by using full automatic biochemical analysor. The plasma antioxidants levels were compared among three groups by one-way ANOVA. Psychopathological symptoms and severities of TD were assessed by using the Positive and Negative Symptom Scale（PANSS）and Abnormal Involuntary Movement Scale (AIMS) respectively，the relationships of the plasma antioxidants levels and the clinical traits of TD were analyzed. Results Plasma Alb and Bil in control group ［(46.8±3.4) g/L，(12.7±3.3) μmol/L］ were significantly higher than those in TD ［(40.2±2.5) g/L，(9.2±2.1) μmol/L］ and non-TD ［(41.2±2.3) g/L，(10.2±3.1) μmol/L］ groups (all P<0.001)，but there were no significant differences on plasma UA concentrations among the three groups (F=1.42，P=0.234). There was significant difference on the Alb concentrations between the TD and non-TD group (P=0.033)，and trend significant difference on Bil levels (P=0.052). In TD group，the total score of AIMS were negatively related with Bil concentrations (r=-0.373，P=0.008) and negative sub-score of PANSS (r=-0.262，P=0.044). Conclusions The non-enzyme antioxidants might be involved in the pathophysiology of TD. Key words: Antipsychotic agents; Dyskinesia，drug-induced; Plasma; Antioxidant; Albumins; Bilirubin; Uric acid