Abstract

 
 
 The main objective of this study was to reveal the circulatory changes in the Penumbra zone of stroke, which was induced by the photochemical method in the cerebral cortex of the rats. It has been revealed that the maximum reduction in blood supply in the penumbra zone during permanent ischemia is achieved 24 hours after the completion of the process of inducing thrombosis of vessels. Therapeutic intervention to save the cells of the Penumbra zone, which are in the initial stages of apoptosis, it is advisable to carry out in the first 12 hours after the onset of stroke.
 
 
Highlights
80-85% of total number of strokes is due to ischemic cerebral infarctions
In a focal cerebral stroke, the ischemic region consists of a central region, with a sharply reduced cerebral blood flow, and a more distal portion of the so-called penumbra zones that are partially supplied with blood by collaterals of adjacent intact vessels (Bhardwaj et al, 2003, Ramos-Cabrer et al, 2011)
In 12 hours, the changes/alterations mentioned above resulted in the following values: local blood flow in the Penumbra zone - 17.8±1.0 ml/100g/min, and in the contralateral side ‒ 55.3±2.7; in this case the difference is statistically reliable (P
Summary
80-85% of total number of strokes is due to ischemic cerebral infarctions (ischemic strokes). It should be emphasized that despite the urgency of the local cerebral infarction problem, the issues related to morphological and functional changes in the Penumbra zone have been insufficiently studied. The issues of structural and functional rearrangements in the Penumbra zone were studied in more detail with the use of models of short-term occlusion of the middle cerebral artery and subsequent reperfusion. In this case, the basic data on morphological rearrangements are based on light-optical studies, and data on ultrastructural shifts in neurons and glial cells of the Penumbra zone are very scarce. Main objective of the current study was the investigation of circulatory changes in the Penumbra zone, induced by photochemical method of local cortex infarction of cerebral hemispheres in rats
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