Abstract
BackgroundRecurrent respiratory tract infection (RRTI) is a disease occurred frequently in preschool children.MethodsA total of 120 RRTI children were randomly divided into active group, remission group, intervention group and control group, meanwhile 30 healthy children were selected as the healthy group. Children in the intervention group were given oral Bifidobaeterium tetravaccine tablets (Live) for 2 months, while the control group received routine treatment. Stool sample were detected to analyze the bacterial strains. The occurrence of respiratory tract infection (RTI) was compared between different groups during 1 year follow-up.ResultsCompared with the healthy group, the number of Bifidobacteria and Lactobacilli in the active group, remission group, intervention group and control group was significantly decreased (P < 0.05). The number of Bifidobacteria and Lactobacilli in the intervention group was significantly higher compared to other RRTI groups (P < 0.05). During the follow-up period, the average annual frequency of different acute RTI and use of antibiotics were significantly reduced (P < 0.05), the average duration of cough, fever and use of antibiotics at each episode were also significantly shortened (P < 0.05) in the intervention group compared to the control group.ConclusionsChildren with RRTI are susceptible to intestinal flora imbalance. Oral probiotics can effectively improve the RRTI intestinal microecological balance in children and reduce the frequency of RTI.
Highlights
Recurrent respiratory tract infection (RRTI) is one of the most common reasons for the pediatric visits and hospitalization
We found that RRTI children suffered from intestinal flora imbalance, which was manifested as a significant reduction in the number of Bifidobacteria and Lactobacilli and an increase in the number of Escherichia coli
This study revealed that the number of Bifidobacteria and Lactobacilli in active stage of RRTI
Summary
Recurrent respiratory tract infection (RRTI) is one of the most common reasons for the pediatric visits and hospitalization. Multiple studies have demonstrated that long-term use of probiotics could significantly reduce the risk of respiratory infections, and could benefit for the fever, cough and administration duration of antibacterial agents in children [5,6,7,8,9]. Among these probiotics, Lactobacillus or Bifidobacterium is the most commonly used [10]. During the follow-up period, the average annual frequency of different acute RTI and use of antibiotics were significantly reduced (P < 0.05), the average duration of cough, fever and use of antibiotics at each episode were significantly shortened (P < 0.05) in the intervention group compared to the control group.
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