Abstract
Cholinergic stimulation of the midline thalamic nuclei reduced active avoidance of a shock prod, passive avoidance of a highly discriminable shock object, and freezing in the presence of stimuli previously associated with shock. However stimulation did not alter flinch or jump thresholds to foot shock, or thresholds for escape from foot shock. These results suggest that alterations of the activity of the midline nuclei directly affect defensive reactions, rather than altering sensory, motor, or general activity processes which may influence avoidance responding.
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