Abstract
HIV-1/Treponema pallidum (T. pallidum) coinfection has become a global challenge, and three monocyte subsets express varying levels of the chemokine receptors CCR2 and CX3CR1. We recently evaluated the association between monocyte subsets and regulatory T cells in HIV-infected individuals with syphilis. Currently, the dynamic changes of CCR2 and CX3CR1 on monocyte subsets during HIV-1 and syphilis coinfection have not been fully investigated. In this study, cell surface staining was used to explore CCR2 and CX3CR1 expression on three monocyte subsets during HIV-1/T. pallidum coinfection. We found that CCR2 densities on the classical monocyte subsets decreased in acute HIV-1 infected (AHI) patients, chronic HIV-1-infected individuals without antiviral therapy (ART) (CHI+ ART–), chronic HIV-1-infected individuals receiving ART (CHI+ART+), rapid plasma reagin-positive (RPR+) individuals, CHI+ ART– plus RPR+ (CHI+RPR+ ART–) individuals, and CHI+ART+ plus RPR+ (CHI+RPR+ART+) individuals. CX3CR1 density increased on the three monocyte subsets during HIV-1 and/or T. pallidum infection. CX3CR1 density on the intermediate and non-classical monocyte subsets in CHI+ ART– individuals was lower than that in CHI+ART+ individuals, and CX3CR1 density on the three monocyte subsets in CHI+ART+ individuals was higher than that in CHI+RPR+ART+ individuals. Our data provide new insight into the roles of CCR2 and CX3CR1 on three monocyte subsets in HIV-1 and T. pallidum pathogenesis.
Highlights
HIV-1/Treponema pallidum (T. pallidum) coinfection has become a global challenge among men who have sex with men (MSM) [1]
We evaluated the changes of CCR2 and CX3CR1 expression on three monocyte subsets at the different stages of HIV-1/T. pallidum coinfection
We found perturbations of CCR2 and CX3CR1 expression on monocyte subsets at the different stages of HIV-1/T. pallidum coinfection
Summary
HIV-1/Treponema pallidum (T. pallidum) coinfection has become a global challenge among men who have sex with men (MSM) [1]. Syphilis infection differentially regulates the phenotype and function of gammadelta T cells at different stages of HIV-1 diseases [7]. The immunological response to syphilis differs during the course of HIV-1 disease progression [8]. T. pallidum-specific antibody activity was reduced in HIV-infected patients with syphilis [9]. We found that the frequency of the classical monocyte subsets was higher in syphilis patients than that in HCs and in syphilis/HIV-1 coinfected patients [15]. The alteration of CCR2 and CX3CR1 expression on three monocyte subsets at different stages of HIV-1 and T. pallidum infection has not been fully investigated. We investigated the alterations of CCR2 and CX3CR1 on the three monocyte subsets during HIV1/T. pallidum coinfection
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
