Alterations in the Serum Urate Concentrations after Bariatric Surgery: a Short-Term Prospective Observational Study.

Abstract

Bariatric surgery is associated with a reduced incidence of hyperuricaemia during the long follow-up time. However, few studies have elucidated the alterations in serum urate (SU) levels in the short-term post-surgery period. To identify the alterations in SU concentrations in individuals with obesity at 1week, 1month, and 3months after bariatric surgery and determine the risk factors for alterations during the first 3 post-surgery months. Thirty-four patients were enrolled. Pre- and post-operative variables were collected at baseline and at each follow-up point. A paired t-test was applied to investigate the relationship between the major parameters. A linear mixed model was performed to analyse the variations of SU concentrations with time. Compared with baseline levels, SU levels significantly increased at 1week, then declined significantly at 1month after surgery (P < 0.05). At the 3-month follow-up, a significant decrease in SU levels was detected compared with that in baseline levels (P< 0.001). In univariate regression analysis, age, sex, weight, body mass index, triglyceride (TG), total cholesterol (TC), creatinine (Cr), and medications were all risk factors for alterations in SU concentrations post-surgery. In the final model, sex, weight, Cr, age, TC, Cr * age, and Cr * TC were established. Surgeons should be cognizant of the significant increase in SU levels in the first postoperative week. Alterations in SU concentrations during the first 3 post-operative months were associated with sex, age, weight, Cr, and TC levels at baseline.