Abstract
1. 1. Increased urinary and hepatic concentrations of d-glucuronic acid, l-ascorbic acid and d-glucaric acid were found within 8 hours after administration of sodium barbital, phenobarbital, nikethamide, DDT and chlorbutol to rats. No alterations in the urinary excretion of glucuronides were observed. 2. 2. Administration of ethanol resulted within 8 hours in a significantly enhanced excretion of glucuronides, whereas the glucuronic acid pathway was not stimulated. This suggests that stimulation of the glucuronic acid pathway and acceleration of glucuronide formation are not necessarily related. 3. 3. Treatment of rats with compounds capable of stimulating the glucuronic acid pathway did not influence the in vitro activities of hepatic uridine diphosphate glucose dehydrogenase and UDPglucuronyltransferase within 8 hours. 4. 4. The stimulative agents significantly enhanced both uridine diphosphate glucose (UDPG) and uridine diphosphate glucuronic acid (UDPGA) concentrations in the liver. This suggests that stimulation of the glucuronic acid pathway is based on an enhanced availability of UDPG.
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