Abstract

Sufficient evidence is now at hand to indicate that in a certain number of patients suffering from fibrillation of the auricles (about 50 per cent.), oral administration of quinidine sulphate serves to restore the normal rhythm. It is the purpose of this communication to record the mechanism of the heart's action which has been observed in the first eleven patients who have received quinidine in this hospital.Five hundred and seven electrocardiograms taken on eleven patients have been measured and analyzed. After a preliminary dose of .2 to .4 gm. of quinidine to test for the presence of an idiosyncrasy to members of the cinchona group, .4 gm. of the drug has been given by mouth, in gelatin capsules, either three times daily or every two hours, until either the establishment of normal rhythm or the appearance of untoward symptoms indicated cessation of therapy. No more than 2.0 gm. of quinidine were administered in twenty-four hours, though treatment has been continued daily for as long as ten days.Electr...

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